The Turkish Journal of Pediatrics 2011 , Vol 53 , Num 6
Transforming Growth Factor-Beta1 (509 C/T, 915 G/C, 869 T/C) Polymorphisms Are Not Related to Obesity in Turkish Children
Departments of 1Pediatrics, 2Medical Biology, and 3Biostatistics, Başkent University Faculty of Medicine, Ankara, Turkey Kanra AR, Tulgar-Kınık S, Verdi H, Ataç FB, Yazıcı AC, Özbek N. Transforming growth factor-beta1 (509 C/T, 915 G/C, 869 T/C) polymorphisms are not related to obesity in Turkish children. Turk J Pediatr 2011; 53: 645-650.

Increasing expression of transforming growth factor-beta 1 (TGF-β1) from fatty tissue affects the serum level and hence may stimulate expression of the other cytokines. The studies concerning the relation between TGF-β1 polymorphisms and obesity have been performed in adults, and diverse results have been reported. In this study, we aimed to investigate the association of TGF-β1 509 C/T, 915 G/C, 869 T/C polymorphisms in childhood obesity and related pathologies.

Two hundred and seventy-one children and adolescents were included in the study. One hundred and twenty-one of these cases were in the Obese Group and 150 were in the Control Group. In the Obesity Group, we searched the carbohydrate and lipid metabolism disorders such as insulin resistance, dyslipidemia and hepatosteatosis.

The results of this study revealed the lack of an association between TGF-β1 509 C/T, 915 G/C and 869 T/C polymorphisms and obesity. There were no relations between the polymorphism genotypes and obesity-related metabolic disturbances. Keywords : obesity, children, transforming growth factor-β1 gene polymorphism.

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