The Turkish Journal of Pediatrics 2010 , Vol 52 , Num 3
Effect of Glutamine Supplementation on Lymphocyte Subsets in Children with Acute Diarrhea
Units of 1Social Pediatrics, 2Immunology, and 3Hematology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey To study the effect of glutamine supplementation on lymphocyte subpopulation counts in children with acute diarrhea, children aged 6-24 months were enrolled in a double-blind randomized study. Cases had received either 0.3 g/kg/day of glutamine or placebo orally for seven days. The counts of blood leukocytes, lymphocytes and lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD16+CD56+) were determined both on admission and seven days later using a flow cytometry. When adjusting for sex, current breastfeeding status, dehydration, and nutritional status of children, lymphocyte subpopulations did not differ significantly between the glutamine- and placebo-supplemented groups on the 7th day of intervention. Keywords : lymphocyte subset, acute diarrhea, glutamine, children, supplementation
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