The Turkish Journal of Pediatrics 2010 , Vol 52 , Num 1
Persistent pulmonary hypertension of the newborn refractory to inhaled nitric oxide treated with milrinone: a case report
Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy Current therapy of persistent pulmonary hypertension of the newborn (PPHN) consists of optimal ventilation, hemodynamic support and selective vasodilatation with inhaled nitric oxide (iNO). We present herein a case of PPHN non-responsive to iNO but treated successfully with a combination of iNO and intravenous milrinone, a phosphodiesterase III inhibitor.

This case suggests that the drug may be a useful adjunctive treatment in the management of PPHN. Keywords : milrinone, pulmonary hypertension, newborn, phosphodiesterase III inhibitor.

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