The Turkish Journal of Pediatrics
2010 , Vol 52 , Num 1
Nosocomial transmission of Candida pelliculosa fungemia in a pediatric intensive care unit and review of the literature
Departments of 1Microbiology, 2Infectious Diseases and Infection Control Committee, and 3Pediatrics, Gazi University Faculty
of Medicine, Ankara, Turkey, and 4Department of Microbiology, Meiji Pharmaceutical University, Kiyose, Tokyo, JapanBCncell
Horizontal transmission of Candida species in the hospital environment
and the fungemia rates have increased in the past decade. We describe a
nosocomial cluster of fungemia caused by Candida pelliculosa (teleomorph
Pichia anomala) in four infants hospitalized in the pediatric intensive care unit.
Candida isolates had strictly related fingerprints, as generated by randomly
amplified polymorphic DNA analysis using five different primer sets. The four
babies were all treated successfully and recovered. All of the isolates were
susceptible to the antifungals tested including amphotericin B, flucytosine,
fluconazole, miconazole, micafungin, itraconazole, and voriconazole. Infection
control procedures were adapted in the unit and no relapse was detected.
In addition, 30 publications presenting 450 pediatric and 28 adult cases are
reviewed.
Keywords :
Candida pelliculosa, Pichia anomala, fungemia, nosocomial, pediatric
intensive care unit.