The Turkish Journal of Pediatrics 2008 , Vol 50 , Num 6
Intestinal intussusception due to a pyogenic granuloma
1Institute of Pathology, University of Belgrade, Serbia
2Department of Histopathology, Royal Liverpool Children’s NHS Trust – Alder Hey Hospital, Liverpool, United Kingdom
3Departments of Pediatric Surgery, University Children’s Hospital, Belgrade, Serbia
4Departments of Pediatric Gastroenterology, University Children’s Hospital, Belgrade, Serbia
Stojsic Z, Brasanac D, Kokai G, Vujovic D, Zivanovic D, Boricic I, Bacetic D. Intestinal intussusception due to a pyogenic granuloma. Turk J Pediatr 2008; 50: 600-603.

Pyogenic granuloma (PG), also known as lobular capillary hemangioma, is a benign vascular tumor, most commonly arising on the skin and the oral mucosa. Gastrointestinal localization of PG, except for the oral cavity, is exceptionally rare. We describe a case of ileal PG occurring in a 13-year-old girl, presenting with intestinal obstruction.

Histological examination revealed proliferation of capillary-sized vessels, with prominent intravascular component, involving the entire thickness of the intestinal wall. Immunohistochemistry showed positivity for CD31, CD34 and von Willebrand factor, whereas immunostaining for glucose transporter- 1 protein (GLUT1) and for human herpes virus 8 (HHV-8) was negative. We suggest that PG should be considered in the differential diagnosis of childhood gastrointestinal polypoid lesions. Keywords : child, intestinal obstruction, pyogenic granuloma, small bowel

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