The Turkish Journal of Pediatrics
2020 , Vol 62 , Num 5
Successful treatment of pediatric post-liver transplant Kaposi`s sarcoma with paclitaxel
1 Division of Pediatric Oncology, Health Sciences University, Okmeydanı Training and Research Hospital, İstanbul, Turkey2 Department of Pediatrics, Health Sciences University, Okmeydanı Training and Research Hospital, İstanbul, Turkey
3 Department of Pathology, Acıbadem University School of Medicine, İstanbul, Turkey
4 Departments of Pediatric Gastroenterology, Memorial Şişli Hospital, İstanbul, Turkey
5 Pediatric Surgery and Liver Transplantation Center, Memorial Şişli Hospital, İstanbul, Turkey DOI : 10.24953/turkjped.2020.05.020 Background. Kaposi`s sarcoma (KS) is a complication of immunosuppressive therapy for transplant recipients. Unlike adult recipients, KS in pediatric organ transplantation is quite rare. Treatment is usually withdrawal of immunosuppression; non-responders often receive chemotherapy.
Case. We have reported a child with post-liver transplant visceral KS which has progressed despite withdrawal of immunosuppressive therapy, who has been treated with Paclitaxel for three weeks. KS has regressed completely after four cycles of Paclitaxel.
Conclusion. Paclitaxel should be considered as an effective first line treatment option for patients with posttransplant KS.
Keywords : Kaposi`s sarcoma, children, paclitaxel