The Turkish Journal of Pediatrics 2020 , Vol 62 , Num 3
Immediate adverse reactions to intravenous immunoglobulin in primary immune deficiencies: a single center experience
Ercan Nain 1 ,Ayça Kıykım 1 ,Nurhan Aruci Kasap 1 ,Safa Barış 1 ,Ahmet Özen 1 ,Elif Karakoç Aydıner 1
1 Division of Pediatric Allergy and Immunology, Department of Pediatrics, Marmara University Faculty of Medicine, İstanbul, Turkey DOI : 10.24953/turkjped.2020.03.004 Background and objective. Adverse reactions related to intravenous immunoglobulin (IVIG) infusions vary from 1 to 81%, with an average of 20%. They may be classified as immediate; occurring during the infusion itself or delayed; occurring after the infusion has been ceased. In the present study, we aimed to evaluate the frequency of immediate adverse reactions due to IVIG infusions in primary immune deficiency (PID) patients.

Methods. The study population was composed of 109 patients. A total of 763 infusions were recorded for demographic data and adverse reactions.

Results. The participants included 32 girls (29%) and 77 boys (71%). The mean age was 11.8 ± 5.7 years (0.6- 33.5 years). Early adverse events (AE) were recorded in 34 (4.5%) among 763 IVIG infusions including 30 mild (88.2%), 3 moderate (8.8%) and 1 severe (2.9%). The most common immediate adverse reactions were fever (29.4%) and headache (29.4%). The risk of AE was higher among primary antibody deficiency (PAD), compared to combined immunodeficiency (OR 2.61, 95%CI 1.061-6.475; p = 0.037).

Conclusions. Use of various intravenous immunoglobulin treatments should be considered with regard to side effect profiles observed. In our cohort, PID patient experienced mostly mild AE; PAD was associated with an increased risk of AE. Keywords : IVIG, adverse reaction, primary immunodeficiencies

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