The Turkish Journal of Pediatrics 2019 , Vol 61 , Num 6
The lung microbiome in neonates
Dhivya Lakshmi Permall 1 ,Asfia Banu Pasha 1 ,Xiao-qing Chen 1 ,Hong-yan Lu 2
1 Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, No 300, Guangzhou Road, Nanjing, Jiangsu Province
2 Department of Pediatrics, Affiliated Hospital of Jiangsu University, Zhenjiang, China
DOI : 10.24953/turkjped.2019.06.001 Permall DL, Pasha AB, Chen XQ, Lu HY. The lung microbiome in neonates. Turk J Pediatr 2019; 61: 821-830.

Despite the advent of culture-independent techniques to identify members of the microbiome, studies focusing on the lung microbiome of neonates are scarce. Understanding the role of the microbiome in the pathogenesis of pulmonary conditions affecting newborns could lead to the initiation of pioneering therapeutic interventions, which could potentially prevent lifelong disability. Bronchopulmonary dysplasia (BPD) has been associated with a less diverse microbiome, presence of Ureaplasma species and reduced Lactobacillus detection. Additionally, the potential role of microbial dysbiosis in the pathogenesis of asthma, cystic fibrosis and pneumonia has been described. There has also been a surge of interest in attempting to elucidate the interactions between the airway and gut microbiomes and their bearings on respiratory health and diseases to eventually broaden the scope of therapeutic interventions. Keywords : airway, bronchopulmonary dysplasia, lung, microbiome, newborn

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