The Turkish Journal of Pediatrics 2019 , Vol 61 , Num 5
The effect of 2000 ıu/day vitamin D supplementation on insulin resistance and cardiovascular risk parameters in vitamin D deficient obese adolescents
Meliha Esra Bilici 1 ,Şenay Savaş Erdeve 2 ,Semra Çetinkaya 2 ,Zehra Aycan 2
1 Clinic of Pediatrics, Health Sciences University, Dr. Sami Ulus Obtetrics and Gynecology, Children’s Health and Disease Training and Research Hospital, Ankara, Turkey
2 Clinic of Pediatric Endocrinology, Health Sciences University, Dr. Sami Ulus Obtetrics and Gynecology, Children’s Health and Disease Training and Research Hospital, Ankara, Turkey
DOI : 10.24953/turkjped.2019.05.011 Bilici ME, Savaş Erdeve Ş, Çetinkaya S, Aycan Z. The effect of 2000 ıu/day vitamin D supplementation on insulin resistance and cardiovascular risk parameters in vitamin D deficient obese adolescents. Turk J Pediatr 2019; 61: 723-732.

The aim of this study was to determine the vitamin D deficiency prevalence in obese adolescents and to investigate the effect of vitamin D supplementation on insulin resistance and cardiovascular risk parameters in obese adolescents with vitamin D deficiency. Ninety-six obese adolescents aged 10-18 years were divided in 2 groups according to their vitamin D levels: Deficient group (<12ng/ ml) and sufficient group (≥12ng/ml). All patients in the vitamin D deficiency group were recommended 2000IU/day vitamin D supplementation. Fifty four (56.3%) patients had vitamin D deficiency. The only difference between the two groups was PTH level which was higher in the vitamin D deficiency group. Vitamin D reached sufficient levels in 22 (95.6%) out of the 23 patients with the 3 month supplementation of 2000 IU/day vitamin D. There was a significant decrease in weight Standard Deviation Score (SDS), Body Mass Index (BMI) SDS, hip circumference, total cholesterol, LDL, HbA1c, AST, PTH and interleukin-6 while no significant change was seen in measurements of glucose, insulin, HOMA-IR, C-peptide and the rate of metabolic syndrome. There were decreases in levels of total cholesterol and LDL with vitamin D treatment, while there was no significant change in insulin resistance. Vitamin D reduced interleukin-6 levels by its antiinflammatory effect. Keywords : cardiovasculer risk, insulin resistance, obesity, vitamin D.

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