The Turkish Journal of Pediatrics 2017 , Vol 59 , Num 2
Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients
Arash Salmaninejad 1-2 ,Mahdi Mahmoudi 1-2-3 ,Saeed Aslani 1-2-3 ,Shiva Poursani 1 ,Vahid Ziaee 4-5 ,Nima Rezaei 6-7-8
1 Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Student Research Committee, Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Rheumatology Expert Group (REG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
4 Pediatric Rheumatology Research Group, Rheumatology Research Center
5 Division of Pediatric Rheumatology, Pediatrics Center of Excellence
6 Department of Immunology, School of Medicine
7 Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
8 Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, UK
DOI : 10.24953/turkjped.2017.02.005 Salmaninejad A, Mahmoudi M, Aslani S, Poursani S, Ziaee V, Rezaei N. Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients. Turk J Pediatr 2017; 59: 144-149.

Juvenile-onset systemic lupus erythematosus (JSLE) is a complex autoimmune disease, characterized by multi-organ involvement. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene have been reported to have relationship with the risk of several autoimmune diseases. Studies have provided evidence that STAT4 may participate in the pathogenesis of JSLE. Therefore, we aimed to evaluate the association of STAT4 SNPs with JSLE in Iranian population. In this case-control study, two SNPs of STAT4 gene, including rs7574865 and rs7601754 were genotyped in 50 Iranian JSLE patients and 281 matched healthy individuals using real-time PCR allelic discrimination approach. Our experiments demonstrated that G and T alleles of rs7574865 SNP had similar distribution between patients and controls (P = 0.16). Additionally, differences in frequency of GG, GT, and TT genotypes (P = 0.14, 0.29, and 0.54, respectively) were not significant. Likewise, A and G alleles, as well as genotypes of rs7601754 SNP did not show significant differences between JSLE patients and healthy individuals. Lack of association of rs7574865 and rs7601754 SNPs in STAT4 gene with susceptibility to JSLE in Iranian population, despite their association with the risk of adult SLE in the same population, implicates on difference of genetic background of JSLE and SLE. Keywords : children, juvenile systemic lupus erythematosus, SLE, SNP, STAT4

Copyright © 2016 turkishjournalpediatrics.org