The Turkish Journal of Pediatrics
2016 , Vol 58 , Num 2
Venlafaxine intoxication in an adolescent presenting with severe lactic acidosis
1 Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey2 Pediatric Intensive Care Unit, Ankara University Faculty of Medicine, Ankara, Turkey DOI : 10.24953/turkjped.2016.02.012 Venlafaxine is a selective serotonin noradrenaline reuptake inhibitor and commonly prescribed antidepressant in adults. Most patients overdosing with venlafaxine develop only mild symptoms. Severe toxicity is reported with the most common symptoms being CNS depression, serotonin toxicity, seizure, or cardiac conduction abnormalities. However, lactic acidosis is an uncommon adverse effect. Here, we present the first case in the literature reporting lactic acidosis due to venlafaxine overuse in an adolescent. Keywords : venlafaxine, overdose, lactic acidosis, adolescent