The Turkish Journal of Pediatrics 2016 , Vol 58 , Num 2
Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever
Aydilek Dağdeviren-Çakır 1 ,Ahmet Arvas 2 ,Kenan Barut 3 ,Emel Gür 2 ,Özgür Kasapçopur 3
1 Division of Pediatric Endocrinology, İstanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey
2 Division of Social Pediatrics an, İstanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey
3 Division of Pediatric Rheumatology, İstanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey
DOI : 10.24953/turkjped.2016.02.001 The aim of this study was to determine the frequency of vitamin D deficiency and/or insufficiency in children with juvenile idiopathic arthritis (JIA) and familial Mediterranean fever (FMF) and to assess the relationship between vitamin D and disease activity. Sixty four patients with JIA, thirty six patients with FMF and one hundred healthy children were enrolled in this study. Vitamin D levels were measured during activation and remission periods in the patients with JIA and during attack and attack free periods in the patients with FMF. The mean vitamin D levels were found to be 18. 9±11 ng/ml and 18.6±9.2 ng/ml during activation and remission periods of disease, respectively, in the patients with JIA, 16±8.5 ng/ml and 13.1±6.4 ng/ml during attack and attack-free periods, respectively, in the patients with FMF and 26.7±10.5 ng/ml in the healthy children. There was no significant difference between vitamin D levels during activation and remission periods in the patients with JIA, whereas vitamin D levels during attack free periods were lower compared to attack periods in the patients with FMF. No significant relationship was found between disease activity and serum vitamin D levels. The vitamin D levels of the children with JIA and FMF were significantly lower compared to the healthy children. The frequency of vitamin D deficiency and insufficiency was considerably high among the patients with JIA and FMF. Keywords : juvenile idiopathic arthrtitis, familial Mediterranean fever, vitamin D, children, disease activity
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