The Turkish Journal of Pediatrics 2015 , Vol 57 , Num 2
Intractable Colitis Associated with Chronic Granulomatous Disease in Young Girl
Divisions of 1Pediatric Gastroenterology, 2Pediatric Allergy and Immunology and 4Pediatric Infectious Diseases, Department of Pediatrics, and 3Department of Pathology, Ankara University Faculty of Medicine, Ankara, Turkey.
Chronic granulomatous disease (CGD) is an autosomal recessive or X-linked disorder caused by NADPH oxidase deficiency leading to an impaired ability of reactive superoxide anion and metabolite formation and recurring severe bacterial and fungal infections, with a high mortality rate. Diarrhea, colitis, ileus, perirectal abscess formation and anal fissures are reported gastrointestinal findings in these patients. We report a case of intractable colitis associated with CGD in a young girl. Keywords : chronic granulomatous disease, colitis, children.
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