The Turkish Journal of Pediatrics 2014 , Vol 56 , Num 4
Chronic Eosinophilic Leukemia with Monosomy 8 in a Five-Year-Old Girl: A Rare Case
Units of 1Pediatric Hematology, 4Radiology and 7Ophthalmology, Dr. A. Y. Ankara Oncology Research and Training Hospital, Departments of 2Genetics and 5Pathology, Ankara University Faculty of Medicine, Units of 3Pediatric Bone Marrow Transplantation, 9Pediatric Pulmonology and 10Radiology, Hacettepe University Faculty of Medicine, 6Kesit Pathology Laboratory, 8Unit of Pediatric Cardiology, Ankara Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
A 5-year-old girl was admitted to our hospital due to fatigue and fever lasting for six months. She had systolic murmur in the mesocardiac and apex regions and hepatosplenomegaly. Laboratory evaluation revealed leukocyte and eosinophil counts of 176 and 144.32 x 109/L, 3.4% blasts in bone marrow and monosomy 8. She developed pulmonary, cardiac, nervous system, ocular and bone involvement. Upon diagnosis of “chronic eosinophilic leukemia, not otherwise specified” (WHO 2008 classification), she received methylprednisolone, vincristine, cytarabine and 6-thioguanine. After hematopoietic stem cell transplantation from a full-matched sibling was performed, the patient expired due to graft failure and septicemia. Keywords : hypereosinophilia, CEL-NOS, monosomy 8.
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