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1^st Department of Pediatrics, P. & A. Kyriakou Children’s Hospital, Athens, Greece
E-mail: labfotis@hotmail.com Hypotensive-hyporesponsive episodes are rare events after immunizations performed for diphtheria, tetanus, Haemophilus influenzae type b and hepatitis B virus vaccines, but most of the reported episodes have been associated with pertussis-containing vaccines. We report the case of a 3-month-old girl, previously healthy otherwise, presenting with the unusual event of a hypotonic- hyporesponsive episode after vaccination with the 13-valent pneumococcal vaccine. Diagnosis was established after a thorough evaluation of the patient and by exclusion of other clinical conditions. Keywords : vaccine, adverse reactions, child, pneumococcal conjugate vaccine, hypotonia