The Turkish Journal of Pediatrics
2014 , Vol 56 , Num 1
Acute tubulointerstitial nephritis-uveitis (TINU) syndrome developed secondary to paracetamol and codeine phosphate use: two case reports
Departments of 1Pediatric Nephrology and 2Pathology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
E-mail: alaygutdemet@gmail.com
Tubulointerstitial nephritis (TIN) refers to a group of heterogeneous diseases
affecting the interstitial compartment of the kidney. It might be primary
or can develop secondary to many urinary systemic diseases. Primary TIN
develops mainly following drug usage, exposure to toxins, and also infections
and humoral and cell-mediated immune reactions. In some patients, signs
of systemic inflammatory reactions can be the first presenting symptoms.
Histopathological evaluation reveals mononuclear cells and lymphocytes
in the interstitium and tubuli. Acute and chronic TIN can resolve after
elimination of the culprit destructive factors, as drugs, toxins and immune
reaction. Combination of tubulointerstitial inflammation and uveitis is termed
as tubulointerstitial nephritis-uveitis (TINU) syndrome. Uveitis might occur
before, after, and also concomitantly with TIN. Herein, two adolescent cases
of TIN and TINU, seemingly developed secondary to paracetamol and codeine
phosphate use, are presented.
Keywords :
tubulointerstitial nephritis, codeine phosphate, paracetamol, over-thecounter
drugs, uveitis, children.