The Turkish Journal of Pediatrics
2012 , Vol 54 , Num 3
Mannose-Binding Lectin Gene Codon 54 Polymorphism Susceptible to Brucellosis in Turkish Children
1Division of Pediatric Infectious Diseases, Dr. Behçet Uz Child Diseases and Pediatric Surgery Training and Research
Hospital, and 2Department of Medical Genetics and 3Division of Pediatric Infectious Diseases, Ege University Faculty of
Medicine, and 4Department of Pediatrics, Tepecik Educational and Research Hospital, İzmir, Turkey
Genetic factors are as important as environmental factors in susceptibility
to brucellosis. Among these genetic factors, mannose-binding lectin (MBL)
deficiency contributes to susceptibility to animal brucellosis. The aim of the
study is to determine the influence of codon 54 polymorphisms in the MBL
gene on susceptibility to brucellosis.
Forty-three patients diagnosed with brucellosis and 106 healthy children
were admitted in the study. In the patient group, 19 (44.2%) subjects had
AA, 22 (51.1%) subjects had AB and 2 (4.6%) subjects had BB genotypes
for codon 54 polymorphism. Eighty-two (77.4%) of the healthy children had
AA genotype, while 24 (22.6%) had AB genotype.
Our results revealed that genotype frequencies carrying MBL variant allele
at codon 54 among the patients were significantly higher compared to those
found in the control group (55.8% and 22.6%, respectively; p=0.0001, odds
ratio [OR]=4.316, 95% confidence interval [CI]: 2.030-9.177). Our data
suggest that children with MBL codon 54 AB or BB genotype are more
susceptible to brucellosis.
Keywords :
mannose binding lectin, brucellosis, susceptibility.
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