The Turkish Journal of Pediatrics 2011 , Vol 53 , Num 6
Hypopituitarism Masquerading as Prasad’s Syndrome: A Case Report
Departments of 1Pediatric Endocrinology, 2Pediatric Hematology and 3Pediatrics, Ankara Children’s Hematology and Oncology Training Hospital, Ankara, Turkey Demirel F, Aksu T, Esen İ, Yaralı N, Karakaya G, Tunç B. Hypopituitarism masquerading as Prasad’s syndrome: a case report. Turk J Pediatr 2011; 53: 702-704.

Prasad’s syndrome is characterized by geophagia, growth retardation, hypogonadism, and zinc deficiency. We report a 15-year-old boy whose medical history and clinical and laboratory findings were fully compatible with Prasad’s syndrome. In addition to severe growth retardation and pubertal delay, iron deficiency anemia and zinc deficiency were determined. His gliadin and endomysium antibodies were negative. The thyroid hormone levels were in normal range but basal gonadotropins and testosterone levels were low for his age. Detailed endocrinological evaluation revealed growth hormone deficiency and hypogonadotropic hypogonadism. Pituitary gland magnetic resonance imaging revealed pituitary hypoplasia. In our opinion, before the diagnosis of Prasad’s syndrome, endocrine evaluation should be done in these patients and hypopituitarism should be ruled out. Hypogonadotropic hypogonadism and growth hormone deficiency may be masked by Prasad’s syndrome. Keywords : Prasad’s syndrome, zinc, hypopituitarism, hypogonadism.

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