The Turkish Journal of Pediatrics 2009 , Vol 51 , Num 4
Isotretinoin (13-Cis-Retinoic Acid)-Associated Premature Ventricular Contractions
1Pediatric Cardiology Unit, Department of Pediatrics, and 2Department of Dermatology, Hacettepe University Faculty of Medicine, Ankara, Turkey Isotretinoin (13-cis-retinoic acid), a synthetic vitamin A derivative, is used to treat a wide variety of dermatologic conditions including severe acne. Isotretinoin can trigger premature ventricular contractions (PVCs). We describe a 17-year-old boy who presented with PVCs on electrocardiogram during isotretinoin (Roaccutane, Roche) treatment for nodular facial acne. Presence of documented PVCs -on electrocardiogram and Holter monitoringand the disappearance of these PVCs after cessation of the treatment strongly suggest isotretinoin-related PVCs in our case. The impact of isotretinoin on ventricular rhythm can not be ruled out in our case as we have revealed the presence of the temporal association of isotretinoin and documented PVCs. Thus, clinicians should be aware of possible arrhythmogenic effect(s) of isotretinoin. Keywords : isotretinoin, ventricular arrhythmia, acne.
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