The Turkish Journal of Pediatrics 2009 , Vol 51 , Num 3
A case of imipramine-associated immune thrombocytopenia
Department of Pediatrics, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey1, Drug-induced immune thrombocytopenia (DITP), excluding heparin-induced thrombocytopenia, is relatively uncommon. It is characterized by drugdependent antibodies that bind to the platelets and cause their destruction when the responsible drug is ingested or injected. Imipramine is a tricyclic antidepressant drug that is one of those used widely for primary enuresis nocturna, attention deficit hyperactivity disorder, depression, and anxiety disorder in children and adolescents. Imipramine rarely causes hematological abnormalities. A five-year-old boy with imipramine-associated antiglobulinpositive immune thrombocytopenia is reported herein, and we also discuss the possible pathogenesis of drug-associated thrombocytopenia. Keywords : imipramine, immune thrombocytopenia.
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