The Turkish Journal of Pediatrics 2012 , Vol 54 , Num 1
Secondary Pseudohypoaldosteronism Caused by Urinary Tract Infection Associated with Urinary Tract Anomalies: Case Reports
Department of Pediatric Nephrology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey Torun-Bayram M, Soylu A, Kasap-Demir B, Alaygut D, Türkmen M, Kavukçu S. Secondary pseudohypoaldosteronism caused by urinary tract infection associated with urinary tract anomalies: case reports. Turk J Pediatr 2012; 54: 67-70.

Secondary pseudohypoaldosteronism type 1 develops due to transient aldosterone resistance in renal tubules and is characterized by renal sodium loss, hyponatremia, hyperkalemia and high plasma aldosterone levels. Although many reasons are described, urinary tract infections and/or urinary tract anomalies are the most common causes. Although the cause of the tubular resistance is not known exactly, renal scar development due to obstruction and reduced sensitivity of mineralocorticoid receptors due to cytokines such as transforming growth factor (TGF)-β are the possible mechanisms. It is seen especially within the first three months of life and the frequency decreases with age. The treatment is usually elimination of the underlying cause. In this article, we present four patients with several urinary tract anomalies and concomitant urinary tract infection who developed transient secondary pseudohypoaldosteronism. Keywords : urinary tract infection, urinary tract anomalies, secondary pseudohypo-aldosteronism.

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