The Turkish Journal of Pediatrics 2010 , Vol 52 , Num 5
Langerhans Cell Histiocytosis of the Sphenoid Sinus: A Case Report
department of Pathology, Yuhuangding Hospital, and 2Department of Human Anatomy, Binzhou Medical University, and 3Binzhou Medical University, Yantai, China Yu G, Huang F, Kong L, Kong X, Zhang L, Xu Q. Langerhans cell histiocytosis of the sphenoid sinus: a case report. Turk J Pediatr 2010; 52: 548-551.

Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is a rare disorder characterized by clonal proliferation and excess accumulation of pathologic Langerhans cells causing local or systemic effects. Bone is the most common organ involved and a single skull lesion is the most frequent presentation of childhood LCH. However, sphenoid sinus is an uncommon condition of involvement in LCH. Here we report a case of LCH in the sphenoid sinus, which occurred in a seven-year-old girl who presented initially with headache. The girl had suffered from headache for one month before she went to an otorhinolaryngologist one week before. Magnetic resonance imaging (MRI) showed a lesion of inflammatory granuloma. Surgery was performed and the disease was diagnosed pathologically as single-site LCH via hematoxylin-eosin (H&E) and immunohistochemical staining. Keywords : Langerhans cell histiocytosis, sphenoid sinus, children

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