The Turkish Journal of Pediatrics 2007 , Vol 49 , Num 2
Isolated testicular and bone relapse in children with acute myeloblastic leukemia and chronic graft versus host disease after allogeneic BMT
1Units of Pediatric Infectious Diseases, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
2Units of Hematology and Bone Marrow Transplantation, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
3Units of Immunology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
Yıldırım İ, Uçkan D, Çetin M, Tuncer M, Tezcan İ. Isolated testicular and bone relapse in children with acute myeloblastic leukemia and chronic graft versus host disease after allogeneic BMT. Turk J Pediatr 2007; 49: 206-209.

Isolated extramedullary relapse after allogeneic bone marrow transplantation (BMT) for acute myeloblastic leukemia (AML) is very unusual, particularly in patients with graft versus host disease (GVHD) known to be associated with decreased incidence of leukemic relapses. However, these rare occasions have been suggested to result from the escape of leukemic cells at the immuneprivileged sites. Here we report two unusual post-transplant cases with AML: the first developed testicular relapse during the treatment of chronic GVHD (cGVHD) and bronchiolitis obliterans and the second relapsed as granulocytic sarcoma in the proximal tibia two years after BMT. Keywords : Extramedullary relapse, acute myeloblastic leukemia, bone marrow transplantation, graft versus host disease, bronchiolitis obliterans

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