Division of Hematology/Oncology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey
Division of Nephrology, Department of Pediatrics, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey
Department of Urology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey
Abstract
Transfusion of platelet concentrates remains the first-line therapy for Glanzmann thrombasthenia in case of bleeding or preparation for surgery. However, development of antibodies to platelet glycoprotein (Gp) IIb/IIIa complex or human leukocyte antigens (HLA) is frequent and the main cause of platelet refractoriness. Recombinant activated factor VII (rFVIIa) is a potent alternative for patients with Glanzmann thrombasthenia with anti-platelet antibodies.
We describe a case of Glanzmann thrombasthenia with alloantibodies to platelet Gp IIb/IIIa complex who underwent a successful pyelolithotomy operation under the coverage of recombinant activated factor VIIa and platelet transfusions.