The Turkish Journal of Pediatrics 2006 , Vol 48 , Num 4
Effective treatment of multifocal aggressive fibromatosis with low-dose chemotherapy
1Departments of Pediatric Oncology Unit, Burhan Nalbantoğlu State Hospital, Nicosia, North Cyprus
2Departments of Pediatrics, Burhan Nalbantoğlu State Hospital, Nicosia, North Cyprus
3Departments of Pathology, Dr. Burhan Nalbantoğlu State Hospital, Nicosia, North Cyprus
4Clinical Genetics Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
Cağlar K, Özyönüm H, Akalın M, Balcı S. Effective treatment of multifocal aggressive fibromatosis with low-dose chemotherapy. Turk J Pediatr 2006; 48: 365-368. Desmoid tumor (aggressive fibromatosis), as a member of a group of borderline neoplasms, is a rare tumor of fibroblastic origin that remains difficult to treat. Treatments with surgery, radiotherapy and different medical protocols including interferon (IFN)-α, hormonal agents such as tamoxifen (anti-estrogen) as well as non-steroidal anti-inflammatory drugs and low-dose antineoplastic agents have been reported. In this report we describe a new patient with multifocal aggressive fibromatosis who was successfully treated with low-dose chemotherapy consisting of methotrexate and vinblastine. Keywords : aggressive fibromatosis, low dose chemotherapy, pediatric
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