The Turkish Journal of Pediatrics 2005 , Vol 47 , Num 1
Subacute sclerosing panencephalitis (SSPE) associated with congenital measles infection
1Departments of Pediatrics, Abant İzzet Baysal University, Düzce Faculty of Medicine, Düzce, Turkey
2Departments of Neurology, Abant İzzet Baysal University, Düzce Faculty of Medicine, Düzce, Turkey
3Departments of Neurosurgery, Abant İzzet Baysal University, Düzce Faculty of Medicine, Düzce, Turkey
Şimşek E, Öztürk A, Yavuz C, Kocabay K. Subacute sclerosing panencephalitis (SSPE) associated with congenital measles infection. Turk J Pediatr 2005; 47: 58-62.

A 13-month-old male presented with repetitive episodes of myoclonic jerks of the head and extremities for two months. His past medical history revealed that his non-immunized mother had measles at the time of delivery. Measles antibody titers in serum and cerebrospinal fluid (CSF) were 1/512 (hemagglutinin inhibition [HI]) and 1/128 HI, respectively. Immunofixation electrophoresis of CSF revealed an oligoclonal IgG band. The magnetic resonance imaging (MRI) of the brain on T2-weighted images showed lesions of high signal intensity in the subcortical white matter. Electroencephalography (EEG) revealed periodic high-amplitude slow waves. Diagnosis of subacute sclerosing panencephalitis (SSPE) was based upon clinical presentation, a characteristic EEG, and abnormal CSF studies. MRI findings supported the diagnosis. To the best of our knowledge, this is only the 3rd case to date, of SSPE-associated congenital measles in the literature. Keywords : Subacute sclerosing panencephalitis (SSPE), congenital measles

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