The Turkish Journal of Pediatrics 2019 , Vol 61 , Num 4
Stevens-Johnson syndrome and toxic epidermal necrolysis: a report of six cases
Ahu Kara 1 ,İlker Devrim 1 ,İlknur Çağlar 1 ,Nuri Bayram 1 ,Selcen Kundak 2 ,Hurşit Apa 3 ,Emir Volkan Altan 4
1 Departments of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Hospital, İzmir, Turkey
2 Departments of Dermatology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey
3 Departments of Pediatrics, Dr. Behçet Uz Children's Hospital, İzmir, Turkey
4 Ophthalmology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey
DOI : 10.24953/turkjped.2019.04.010 Kara A, Devrim İ, Çağlar İ, Bayram N, Kundak S, Apa H, Altan EV. Stevens-Johnson syndrome and toxic epidermal necrolysis: a report of six cases. Turk J Pediatr 2019; 61: 538-543.

Stevens-Johnson syndrome and toxic epidermal necrolysis are severe cutaneous adverse reactions commonly caused by exposure to drugs and can end up with significant morbidity and mortality. We reported our experience with six patients who were diagnosed with Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis with a different clinical presentation. In patients, drugs and Mycoplasma pneumoniae infection were implicated as a trigger. Intravenous Immunoglobulin treatment was given to all patients, and intensive treatment was applied for skin and mucosal lesions. The median period of stay in hospital was 13.5 days. The most common long-term complication was ocular involvement. Among six patients, corneal epithelial defects occurred in one patient. Consequently, ophthalmological evaluation should be performed both at the time of diagnosis and before hospital discharge. Keywords : drug reaction, mycoplasma, Stevens-Johnson syndrome

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