The Turkish Journal of Pediatrics 2018 , Vol 60 , Num 3
Chelation therapy for secondary neonatal iron over load: Lessons learned from rhesus hemolytic disease
Fareed Khdair-Ahmad 1 ,Tariq Aladily 2 ,Olfat Khdair-Ahmad 3 ,Eman F. Badran 4
1 Section of Pediatric Gastroenterology, School of Medicine, The University of Jordan, Amman, Jordan
2 Department of Pathology, School of Medicine, The University of Jordan, Amman, Jordan
3 Department of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan
4 Section of Neonatology, School of Medicine, The University of Jordan, Amman, Jordan
DOI : 10.24953/turkjped.2018.03.018 Khdair-Ahmad F, Aladily T, Khdair-Ahmad O, Badran EF. Chelation therapy for secondary neonatal iron overload: Lessons learned from rhesus hemolytic disease. Turk J Pediatr 2018; 60: 335-339.

Secondary neonatal iron overload occurs with intrauterine and post-natal blood transfusions. Treatment with intravenous Deferoxamine was reported only in four cases in the literature. Herein we report a case of a patient born at 36 weeks of gestation, who had rhesus hemolytic disease. He developed secondary iron overload, causing liver injury, after a total of six blood transfusions: four intrauterine and 2 post-natal transfusion therapies. Intravenous Deferoxamine treatment was started at the age of 45 days due to a ferritin level of 40,000 mg/L, progressive rise of liver enzymes, and worsening cholestasis. Treatment resulted in marked reduction in ferritin level (down to 829 mg/L at the age of 6 months), significant improvement in the liver enzymes, and resolution of cholestasis. Keywords : cholestasis, iron overload, deferoxamine, neonates, intrauterine blood transfusion therapy

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