The Turkish Journal of Pediatrics 2017 , Vol 59 , Num 2
Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report
Meltem Akçaboy 1 ,Sevcan Azime Bakkaloğlu-Ezgü 1 ,Bahar Büyükkaragöz 1 ,Emel Isıyel 1 ,Yasar Kandur 1 ,Enver Hasanoğlu 1 ,Necla Buyan 1
1 Division of Pediatric Nephrology, Department of Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey DOI : 10.24953/turkjped.2017.02.011 Akçaboy M, Bakkaloğlu-Ezgü SA, Büyükkaragöz B, Isıyel E, Kandur Y, Hasanoğlu E, Buyan N. Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report. Turk J Pediatr 2017; 59: 184-188.

SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) is defined as a syndrome that is related to various osteoarticular manifestations and chronic dermatological conditions especially severe acne. SAPHO syndrome is a rare and unusual clinical entity in childhood and treatment choices are variable. We report an 11-year-old girl who suffered from SAPHO syndrome and successfully treated with subcutaneous methotrexate. We report our case in order to take attention to this rare clinical condition in evaluating patients and also to point out that treatment options beyond biologic agents should be the first line treatment in childhood. Keywords : children, methotrexate, SAPHO syndrome, treatment

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