The Turkish Journal of Pediatrics 2016 , Vol 58 , Num 6
Increasing vitamin D deficiency in children from 1995 to 2011
Ji-Hyun Seo 1 ,Hye Jin Chung 4 ,Hye-Jung Kim 2 ,Jung Sook Yeom 1 ,Ji Sook Park 1 ,Eun-Sil Park 1 ,Jae-Young Lim 1 ,Chan-Hoo Park 1 ,Hyang-Ok Woo 1 ,Hee-Shang Youn 1 ,Jun-Je Park 3
1 Departments of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science, Jinju, Korea
2 Departments of Pharmacology, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science, Jinju, Korea
3 Departments of Otolaryngology, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science, Jinju, Korea
4 College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Korea
DOI : 10.24953/turkjped.2016.06.007 Serum concentrations of 25-hydroxy vitamin D3 [25(OH)D3] and vitamin D deficiency have changed over time in Korean children. This study assessed serum 25(OH)D3 concentrations and the prevalence of vitamin D deficiency in children. Serum samples were obtained during 1995 to 2011, and 25(OH)D3 concentrations were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Tests of 948 serum samples showed that median 25(OH)D3 concentrations decreased significantly (P<0.001), and the rates of vitamin D deficiency/insufficiency increased significantly (P<0.001), over 15 years. Median serum 25(OH)D3 was significantly higher in males than in females in 2005–2006 and 2010–2011 (P<0.001), whereas the rates of vitamin D deficiency/insufficiency were higher in subjects aged 11–15 years than in the other two age groups after the year 2000. These increases over time in vitamin D deficiency/insufficiency may be due to the changing lifestyles of children. Outdoor physical activity should be strongly encouraged. Keywords : vitamin D, vitamin D deficiency, children, adolescent
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