The Turkish Journal of Pediatrics 2004 , Vol 46 , Num 2
Acute lymphoblastic leukemia in infants

Sections of Hematology Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey

Sections of Genetics, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey

Abstract

Gürgey A, Yetgin S, Çetin M, Gümrük F, Tuncer AM, Hiçsönmez G. Acute lymphoblastic leukemia in infants. Turk J Pediatr 2004; 46: 115-119.

Between January 1978 and August 1999, 29 infants with newly diagnosed acute lymphoblastic leukemia (ALL) were treated on three consecutive protocols. Eighteen patients with infant ALL diagnosed between 1978-1991 were included in Group 1. In this group, treatment comprised a two-or three-drug induction with prednisolone, vincristine and L-asparaginase, and maintenance therapy consisted of weekly oral administration of mercaptopurine and methotrexate for three years. Group 2: Between 1991 and 1999, 11 infants with ALL were treated by St. Jude Total Therapy XI (n=4) and XIII (n=7) protocols with minor modification. Three years' event-free survival (±SE) was 14±9% in group 1. In group 2, this rate was 25±22% in Total XI and 57±19% in Total XIII. Outcome for infants on protocols Total Therapy XI and XIII improved compared with that of group 1.

Keywords : infant leukemia acute lymphoblastic leukemia high-dose methylprednisolone
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