The Turkish Journal of Pediatrics
2012 , Vol 54 , Num 5
Hypohidrosis and Hyperthermia during Topiramate Treatment in Children
Department of Pediatric Neurology, Çukurova University Faculty of Medicine, Adana, Turkey.
E-mail: fincecik@yahoo.com
Topiramate is one of the newer generation antiepileptic drugs with a
beneficial clinical effect on various seizure types. In this study, we present
the clinical findings of hypohidrosis and hyperthermia with topiramate in
pediatric patients. The data were collected retrospectively on 173 patients
diagnosed as epilepsy on topiramate treatment, and hypohidrosis-related
symptoms induced by topiramate were found in 22 patients. Their mean
age was 64.45±56.63 months. The mean duration of topiramate treatment
was 7.09±2.46 months, and the mean dose was 5.37±1.75 mg/kg/day. All
of the patients complained of hypohidrosis and hyperthermia. Six (27.2%)
of them had facial flushing, 4 (18.1%) had heat sensation and only 1 (4.5%)
had lethargy. Hypohidrosis-related symptoms resolved after discontinuation
of the medication. In conclusion, children treated with topiramate should be
cautioned regarding these potential adverse effects and advised to avoid its
use during the hot summer season.
Keywords :
topiramate, hypohidrosis, hyperthermia, children.