The Turkish Journal of Pediatrics
2012 , Vol 54 , Num 5
A Comparison Study between Candida parapsilosis Sepsis and Candida albicans Sepsis in Preterm Infants
Department of Pediatrics, BaYi Children’s Hospital of the General Military Hospital of Beijing PLA, Beijing, P. R. China.
E-mail: fengzhichun81@sina.com
In this study, we aimed to investigate the clinical characteristics of Candida
parapsilosis sepsis in preterm infants. In this retrospective analysis of the
clinical data of 11 cases of Candida parapsilosis sepsis and 13 cases of C.
albicans sepsis, the two groups were compared for research using one-way
analysis of variance (one-way ANOVA), χ2 test, and non-conditional logistic
regression analysis. Compared to the C. albicans sepsis group, the C. parapsilosis
group demonstrated a significantly lower birth weight (1331.8±252.41 vs.
1721.2±589.08) and significantly longer hospital stay (69.909±20.782 vs.
38.385±19.923) (t’/t = 2.160, -3.787; p=0.045, 0.01, respectively); the
incidences of retinopathy of prematurity (ROP) (72.7% vs. 30.8%), tienam
administration (72.7% vs. 23.1%), pneumothorax, and thoracic closed drainage
(27.3% vs. 0) were higher (χ2=4.196, 5.916, 4.052; p=0.041, 0.015, 0.044,
respectively). Logistic regression analysis indicated only hospital stay and tienam
administration in the regression equation (χ2=18.008, p=0.000). Compared
with C. albicans sepsis, an average length hospital stay and administration
of tienam are the high-risk factors for C. parapsilosis sepsis. With regard to
the other predisposing factors of preterm infant fungal sepsis, there were no
differences between the two groups.
Keywords :
premature infants, sepsis, Candida parapsilosis, Candida albicans, tienam.