The Turkish Journal of Pediatrics 2019 , Vol 61 , Num 5
Early onset inflammatory bowel disease: manifestations, genetics and diagnosis
Bobak Moazzami 1-2 ,Kasra Moazzami 3-4 ,Nima Rezaei 1-5-6
1 Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2 Student Research Committee, Babol University of Medical Sciences, Babol, Iran
3 Massachusetts General Hospital, Harvard Medical School
4 Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, USA
5 Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6 Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, UK
DOI : 10.24953/turkjped.2019.05.001 Moazzami B, Moazzami K, Rezaei N. Early onset inflammatory bowel disease: manifestations, genetics and diagnosis. Turk J Pediatr 2019; 61: 637-647.

Crohn`s disease and ulcerative colitis are immunologically mediated chronic inflammatory conditions, collectively referred to as inflammatory bowel diseases (IBD). While most studies have described the condition in the adult population, recent evidences suggest that IBD in children may represent an etiologically distinct disease from the adult onset IBD. Since a significant proportion of patients diagnosed with IBD demonstrate their clinical manifestations during childhood, knowledge about the disease progression, severity and diagnosis in this particular patient population is crucial. Therefore, in the present study, the clinical manifestations, recent advancements in the genetics of early onset IBD and the clinical approach to diagnoses of IBD in children are described. Keywords : Crohn`s disease, inflammatory bowel diseases, interleukin-10

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