The Turkish Journal of Pediatrics 2016 , Vol 58 , Num 4
Multisystem langerhans cell histiocytosis with thymic involvement diagnosed with anterior mediastinal mass in a 2-month-old boy
Funda Tekkeşin 1 ,Arzu Okur 1 ,Betül Emine Derinkuyu 2 ,Nalan Akyürek 3 ,Aynur Oğuz 1 ,Ceyda Karadeniz 1 ,Faruk Güçlü Pınarlı 1
1 Division of Pediatric Oncology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey
2 Division of Radiology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey
3 Division of Pathology, Department of Pediatrics and Departments of Gazi University Faculty of Medicine, Ankara, Turkey
Thymus gland involvement in Langerhans cell histiocytosis (LCH) is usually part of multi-system disease and may be more common than previously recognized. However, thymic involvement causing an anterior mediastinal mass is an extremely rare presentation of multisystem LCH. Here we report a 2-month-old-boy admitted to hospital with a giant anterior mediastinal mass with multisystem LCH involving the thymus, lungs, liver and skin. The differential diagnosis of mediastinal mass in children should also include LCH, especially multisystem disease. LCH should also be kept in mind in the differential diagnosis of skin lesions in infants, even if spontaneous regression occurs. Keywords : Langerhans cell histiocytosis, thymus, skin, infant
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