Intestinal intussusception due to a pyogenic granuloma
Zorica Stojsic1, Dimitrije Brasanac1, George Kokai2, Dragana Vujovic3, Dragana Zivanovic4, Ivan Boricic1, Dragoljub Bacetic1
1Institute of Pathology, University of Belgrade, Serbia
2Department of Histopathology, Royal Liverpool Children’s NHS Trust – Alder Hey Hospital, Liverpool, United Kingdom
3Departments of Pediatric Surgery, University Children’s Hospital, Belgrade, Serbia
4Departments of Pediatric Gastroenterology, University Children’s Hospital, Belgrade, Serbia
Stojsic Z, Brasanac D, Kokai G, Vujovic D, Zivanovic D, Boricic
I, Bacetic D. Intestinal intussusception due to a pyogenic granuloma. Turk
J Pediatr 2008; 50: 600-603.
Pyogenic granuloma (PG), also known as lobular capillary hemangioma, is
a benign vascular tumor, most commonly arising on the skin and the oral
mucosa. Gastrointestinal localization of PG, except for the oral cavity, is
exceptionally rare. We describe a case of ileal PG occurring in a 13-year-old
girl, presenting with intestinal obstruction.
Histological examination revealed proliferation of capillary-sized vessels, with
prominent intravascular component, involving the entire thickness of the
intestinal wall. Immunohistochemistry showed positivity for CD31, CD34
and von Willebrand factor, whereas immunostaining for glucose transporter-
1 protein (GLUT1) and for human herpes virus 8 (HHV-8) was negative.
We suggest that PG should be considered in the differential diagnosis of
childhood gastrointestinal polypoid lesions.