CD56-immunostaining of the extrahepatic biliary tree as an indicator of clinical outcome in biliary atresia: a preliminary report
Tadao Okada1, Tomoo Itoh2, Fumiaki Sasaki1, Shouhei Honda3, Satsuki Naito3, Satoru Todo3
1Departments of Pediatric Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
2Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan
3Departments of First Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Okada T, Itoh T, Sasaki F, Honda S, Naito S, Todo S. CD56-
immunostaining of the extrahepatic biliary tree as an indicator of clinical outcome
in biliary atresia: a preliminary report. Turk J Pediatr 2008; 50: 542-548.
The aim of this study was to evaluate the usefulness of CD56-immunostaining
using extrahepatic biliary tree (EHBT) specimens as a predictive factor in
biliary atresia (BA). The staining intensity of CD56-stained specimens was
scored in 13 children with BA as follows: 0 = no staining, 1 = weak staining,
2 = moderate staining, and 3 = strong staining. There was strong (score 3)
staining of CD56 in the EHBT specimens of 4 patients with more than 1.5
mg/dl of serum total bilirubin in accordance with a decrease of jaundice. Weak
staining of CD56 was seen in the EHBT specimens of patients with no or only
one episode of postoperative cholangitis. Strong staining of CD56 was noted
in the EHBT specimens of 4 patients who underwent liver transplantation.
Our present findings support the possibility of discriminating between good
and poor prognoses of clinical outcome after Kasai portoenterostomy.