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Association of Campylobacter jejuni infection and Guillain- Barré syndrome: a cohort study in the northwest of Iran
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Mohammad Barzegar1, Asghar Alizadeh1, Vahideh Toopchizadeh2 Saeed Dastgiri3, Jafar Majidi4
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1 Departments of Pediatrics, Tabriz University Medical Sciences School of Medicine, Tabriz, Iran
2 Departments of Rehabilitation, Tabriz University Medical Sciences School of Medicine, Tabriz, Iran
3 Departments of Community Family Medicine, Tabriz University Medical Sciences School of Medicine, Tabriz, Iran
4Departments of Immunology, Tabriz University Medical Sciences School of Medicine, Tabriz, Iran
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Barzegar M, Alizadeh A, Toopchizadeh V, Dastgiri S, Majidi J.
Association of Campylobacter jejuni infection and Guillain-Barré syndrome: a
cohort study in the northwest of Iran. Turk J Pediatr 2008; 50: 443-448.
Recent studies have suggested that Campylobacter jejuni is a common pathogen
causing Guillain–Barré syndrome (GBS). This study aimed to determine the
frequency and clinical and electrophysiological features of C. jejuni infection
in children with GBS. We carried out a prospective study on a cohort of 48
children with GBS admitted to Tabriz Children's Hospital in the northwest of
Iran from January 2003 to March 2005. Serologic investigations were used to
diagnose preceding C. jejuni infection. Evidence of a recent C. jejuni infection
was found in 23 (47.9%) of the patients. C. jejuni-associated GBS patients
were younger than others (p=0.010), and they had a rapid progression to
reach peak disability (p=0.018). Neither the peak disability nor the residual
one-year disability was different between the C. jejuni- positive and C. jejuni negative
patients. The patients with preceding C. jejuni infection were more
likely to have axonal neuropathy (p=0.021).
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