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The Turkish Journal of Pediatrics

 
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Visceral leishmaniasis and Coombs' positive hemolytic anemia: a rare association in an infant treated with liposomal amphotericin B
Embiya Dilber, Erol Erduran, Yasemin Işık
Department of Pediatrics, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey
Summary
Dilber E, Erduran E, Işık Y. Visceral leishmaniasis and Cooms' positive hemolytic anemia: a rare association in an infant treated with liposomal amphotericin B. Turk J Pediatr 2002; 44: 354-356.

Visceral leishmaniasis is a worldwide, disseminated intracellular protozoal infection that usually manifests by fever, hepatosplenomegaly, anemia, thrombocytopenia, leucopenia and hypergammaglobulinemia. Although anemia is a usual finding, Coombs' positive hemolytic anemia has rarely been reported in association with this disease. Pentavalent antimonials have been the preferred treatment for this disease for decades, but increasing numbers of treatment failure with antimony are being reported. Liposomal amphotericin B is a new drug which is highly efficacious in the treatment of visceral leishmaniasis and produces minimal toxicity. Here we report an infant with visceral leishmaniasis associated with Coombs' positive hemolytic anemia who was successfully treated with liposomal amphotericin B.

Keywords: visceral leishmaniasis, Coombs' positive hemolytic anemia, liposomal amphotericin B
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